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Evidence map · e-TNS · migraine

e-TNS for migraine: what the research shows

External trigeminal nerve stimulation for migraine. 65 papers from 2011 to 2026, including 4 meta-analyses, 4 systematic reviews and 6 randomised controlled trials. Each study below links to its source.

65Papers in the corpus
4Meta-analyses
6Randomised controlled trials
21Open-access papers

Study design

Jev labels
Meta-analysis4Systematic review4RCT6Non-randomised trial13Cross-sectional2Narrative review25Guideline1In-vitro study1

9 papers have no confident study-design label yet. Labels are AI-classified by Jev: advisory, not clinician-reviewed.

Papers over time

by publication year
2412 2010–122016–182025–26*

* 2025–26 is still in progress, so its count is incomplete.

Most-cited trials and reviews

by citations
  1. 1

    Migraine prevention with a supraorbital transcutaneous stimulator: a randomized controlled trial.

    RCTSchoenen et al. · 2013 · Neurology · 209 citations
  2. 2

    Acute migraine therapy with external trigeminal neurostimulation (ACME): A randomized controlled trial.

    RCTChou et al. · 2019 · Cephalalgia : an international journal of headache · 170 citations · Open access
  3. 3

    Acute Treatments for Episodic Migraine in Adults: A Systematic Review and Meta-analysis.

    Meta-analysisVanderPluym et al. · 2021 · JAMA · 150 citations
  4. 4

    Non-invasive neuromodulation for migraine and cluster headache: a systematic review of clinical trials.

    Systematic reviewReuter et al. · 2019 · Journal of neurology, neurosurgery, and psychiatry · 80 citations · Open access
  5. 5

    Effects of external trigeminal nerve stimulation (eTNS) on laser evoked cortical potentials (LEP): A pilot study in migraine patients and controls.

    RCTVecchio et al. · 2018 · Cephalalgia : an international journal of headache · 16 citations
  6. 6

    Phase 3 randomized, double-blind, sham-controlled Trial of e-TNS for the Acute treatment of Migraine (TEAM).

    RCTKuruvilla et al. · 2022 · Scientific reports · 13 citations · Open access
  7. 7

    Non-invasive neuromodulation in the acute treatment of migraine: a systematic review and meta-analysis of randomized controlled trials.

    Meta-analysisClark et al. · 2022 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 13 citations
  8. 8

    A post hoc analysis of migraine-associated symptoms from the phase 3 randomized, double-blind, sham-controlled Trial of External trigeminal nerve stimulation for the Acute treatment of Migraine (TEAM) study.

    RCTPanza et al. · 2025 · Headache · 1 citations · Open access

Recent trials and reviews

last 3 years
  1. 1

    A post hoc analysis of migraine-associated symptoms from the phase 3 randomized, double-blind, sham-controlled Trial of External trigeminal nerve stimulation for the Acute treatment of Migraine (TEAM) study.

    RCTPanza et al. · 2025 · Headache · 1 citations · Open access

Decision support only. This page summarises published literature; it is not medical advice or a recommendation for any patient. Study designs and topic labels are AI-classified by Jev: advisory, not clinician-reviewed. Abstracts are not reproduced here: follow the links to read each source. Data snapshot 2026-09-25.