Evidence map · nVNS · migraine and cluster headache
nVNS for migraine and cluster headache: what the research shows
Non-invasive vagus nerve stimulation for migraine and cluster headache. 117 papers from 2013 to 2025, including 3 meta-analyses, 2 systematic reviews and 23 randomised controlled trials. Each study below links to its source.
117Papers in the corpus
3Meta-analyses
23Randomised controlled trials
48Open-access papers
Study design
Jev labels21 papers have no confident study-design label yet. Labels are AI-classified by Jev: advisory, not clinician-reviewed.
Papers over time
by publication yearMost-cited trials and reviews
by citations- 1
Non-invasive vagus nerve stimulation for PREVention and Acute treatment of chronic cluster headache (PREVA): A randomised controlled study.
- 2
Non-Invasive Vagus Nerve Stimulation for the ACute Treatment of Cluster Headache: Findings From the Randomized, Double-Blind, Sham-Controlled ACT1 Study.
- 3
Noninvasive vagus nerve stimulation as acute therapy for migraine: The randomized PRESTO study.
- 4
Non-invasive vagus nerve stimulation for the acute treatment of episodic and chronic cluster headache: A randomized, double-blind, sham-controlled ACT2 study.
- 5
Non-invasive vagus nerve stimulation (nVNS) for the preventive treatment of episodic migraine: The multicentre, double-blind, randomised, sham-controlled PREMIUM trial.
- 6
Noninvasive vagus nerve stimulation for migraine: a systematic review and meta-analysis of randomized controlled trials.
- 7
Effects of non-invasive vagus nerve stimulation on attack frequency over time and expanded response rates in patients with chronic cluster headache: a post hoc analysis of the randomised, controlled PREVA study.
- 8
Inter-ictal assay of peripheral circulating inflammatory mediators in migraine patients under adjunctive cervical non-invasive vagus nerve stimulation (nVNS): A proof-of-concept study.
Recent trials and reviews
last 3 years- 1
Noninvasive vagus nerve stimulation for migraine: a systematic review and meta-analysis of randomized controlled trials.
Decision support only. This page summarises published literature; it is not medical advice or a recommendation for any patient. Study designs and topic labels are AI-classified by Jev: advisory, not clinician-reviewed. Abstracts are not reproduced here: follow the links to read each source. Data snapshot 2026-09-25.