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Evidence map · REN · migraine

REN for migraine: what the research shows

Remote electrical neuromodulation for migraine. 74 papers from 2019 to 2026, including 4 meta-analyses, 7 systematic reviews and 9 randomised controlled trials. Each study below links to its source.

74Papers in the corpus
4Meta-analyses
9Randomised controlled trials
23Open-access papers

Study design

Jev labels
Meta-analysis4Systematic review7RCT9Non-randomised trial7Cohort9Cross-sectional1Narrative review21Guideline2

14 papers have no confident study-design label yet. Labels are AI-classified by Jev: advisory, not clinician-reviewed.

Papers over time

by publication year
189 201920222026*

* 2026 is still in progress, so its count is incomplete.

Most-cited trials and reviews

by citations
  1. 1

    Remote Electrical Neuromodulation (REN) Relieves Acute Migraine: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial.

    RCTYarnitsky et al. · 2019 · Headache · 154 citations · Open access
  2. 2

    Acute Treatments for Episodic Migraine in Adults: A Systematic Review and Meta-analysis.

    Meta-analysisVanderPluym et al. · 2021 · JAMA · 150 citations
  3. 3

    Efficacy and safety of remote electrical neuromodulation in migraine: a comprehensive systematic review and meta-analysis.

    Meta-analysisAlnajjar et al. · 2025 · BMC neurology · 3 citations · Open access
  4. 4

    Mechanism-Based Therapeutics In Migraine: Current Evidence And Future Directions

    Systematic reviewZofia Alicja Pojmańska et al. · 2025 · African Journal of Biomedical Research · 0 citations

Recent trials and reviews

last 3 years
  1. 1

    Efficacy and safety of remote electrical neuromodulation in migraine: a comprehensive systematic review and meta-analysis.

    Meta-analysisAlnajjar et al. · 2025 · BMC neurology · 3 citations · Open access
  2. 2

    Mechanism-Based Therapeutics In Migraine: Current Evidence And Future Directions

    Systematic reviewZofia Alicja Pojmańska et al. · 2025 · African Journal of Biomedical Research · 0 citations

Decision support only. This page summarises published literature; it is not medical advice or a recommendation for any patient. Study designs and topic labels are AI-classified by Jev: advisory, not clinician-reviewed. Abstracts are not reproduced here: follow the links to read each source. Data snapshot 2026-09-25.