Evidence map · PNS · central sleep apnea
PNS for central sleep apnea: what the research shows
Transvenous phrenic nerve stimulation for central sleep apnea. 119 papers from 1980 to 2026, including 6 meta-analyses, 2 systematic reviews and 13 randomised controlled trials. Each study below links to its source.
119Papers in the corpus
6Meta-analyses
13Randomised controlled trials
7Open-access papers
Study design
Jev labels21 papers have no confident study-design label yet. Labels are AI-classified by Jev: advisory, not clinician-reviewed.
Papers over time
by publication year* 2025–26 is still in progress, so its count is incomplete.
Most-cited trials and reviews
by citations- 1
Phrenic nerve stimulation to treat patients with central sleep apnoea and heart failure.
- 2
Sustained 12 Month Benefit of Phrenic Nerve Stimulation for Central Sleep Apnea.
- 3
Improving Nocturnal Hypoxemic Burden with Transvenous Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea.
- 4
Meta-Analysis Comparing Outcomes of Therapies for Patients With Central Sleep Apnea and Heart Failure With Reduced Ejection Fraction.
- 5
Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea: A Pooled Cohort Analysis.
- 6
Effect of phrenic nerve stimulation on patients with central sleep apnea: A meta-analysis.
- 7
Meta-analysis of Usefulness of Phrenic Nerve Stimulation in Central Sleep Apnea.
- 8
Transvenous phrenic nerve stimulation to treat central sleep apnoea in patients with heart failure may improve sleep, quality of life, and symptoms.
Recent trials and reviews
last 3 years- 1
Changes in quality of life in patients with atrial fibrillation and central sleep apnea treated with transvenous phrenic nerve stimulation.
- 2
Determinants of transvenous phrenic nerve stimulation-induced improvements in left ventricular function in central sleep apnea and heart failure.
- 3
Win ratio analysis of transvenous phrenic nerve stimulation to treat central sleep apnoea in heart failure.
- 4
Transvenous phrenic nerve stimulation for treating central sleep apnea may regulate sleep microstructure.
- 5
Effect of phrenic nerve stimulation on patients with central sleep apnea: A meta-analysis.
Decision support only. This page summarises published literature; it is not medical advice or a recommendation for any patient. Study designs and topic labels are AI-classified by Jev: advisory, not clinician-reviewed. Abstracts are not reproduced here: follow the links to read each source. Data snapshot 2026-09-25.