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Evidence map · DBS · Parkinson’s disease

DBS for Parkinson’s disease: what the research shows

Deep brain stimulation for Parkinson’s disease. 9,164 papers from 1993 to 2026, including 154 meta-analyses, 201 systematic reviews and 242 randomised controlled trials. Each study below links to its source.

9,164Papers in the corpus
154Meta-analyses
242Randomised controlled trials
2,531Open-access papers

Study design

Jev labels
Meta-analysis154Systematic review201RCT242Non-randomised trial1,174Cohort849Case-control23Cross-sectional229Case series194

2,916 papers have no confident study-design label yet. Labels are AI-classified by Jev: advisory, not clinician-reviewed.

Papers over time

by publication year
2,8461,423 1990–942005–092025–26*

* 2025–26 is still in progress, so its count is incomplete.

Most-cited trials and reviews

by citations
  1. 1

    A randomized trial of deep-brain stimulation for Parkinson's disease.

    RCTDeuschl et al. · 2006 · 1,876 citations
  2. 2

    Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial.

    RCTWeaver et al. · 2009 · 1,021 citations
  3. 3

    Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease.

    RCTDeep-Brain Stimulation for Parkinson's Disease Study Group et al. · 2001 · 954 citations
  4. 4

    Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease.

    RCTFollett et al. · 2010 · 857 citations
  5. 5

    Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trial.

    RCTWilliams et al. · 2010 · 488 citations · Open access
  6. 6

    Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial.

    RCTOdekerken et al. · 2013 · 486 citations
  7. 7

    Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study.

    RCTWitt et al. · 2008 · 415 citations
  8. 8

    Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial.

    RCTOkun et al. · 2009 · 384 citations

Recent trials and reviews

last 3 years
  1. 1

    Treatment of Dysphonia in Patients with Parkinson's Disease: A Scoping Review.

    Systematic reviewAbarca et al. · 2026 · 0 citations
  2. 2

    Neural correlates of emotional prosody in Parkinson's disease: A systematic review.

    Systematic reviewLuciano et al. · 2026 · 0 citations
  3. 3

    Genotype-associated outcomes after deep brain stimulation in Parkinson's disease: a systematic review, meta-analysis and epigenetic implications.

    Meta-analysisLimanówka et al. · 2026 · 0 citations
  4. 4

    Freezing of Gait in Parkinson's Disease: A Scoping Review on the Path Towards Real-Time Therapies.

    Systematic reviewSinghal et al. · 2026 · 0 citations · Open access
  5. 5

    fMRI-based deep brain stimulation programming for Parkinson's disease: a blinded, crossover clinical trial.

    RCTSantyr et al. · 2026 · 0 citations

Decision support only. This page summarises published literature; it is not medical advice or a recommendation for any patient. Study designs and topic labels are AI-classified by Jev: advisory, not clinician-reviewed. Abstracts are not reproduced here: follow the links to read each source. Data snapshot 2026-09-25.