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Evidence map · DBS · essential tremor

DBS for essential tremor: what the research shows

Deep brain stimulation for essential tremor. 1,415 papers from 1993 to 2026, including 20 meta-analyses, 36 systematic reviews and 25 randomised controlled trials. Each study below links to its source.

1,415Papers in the corpus
20Meta-analyses
25Randomised controlled trials
380Open-access papers

Study design

Jev labels
Meta-analysis20Systematic review36RCT25Non-randomised trial151Cohort166Case-control1Cross-sectional27Case series49

407 papers have no confident study-design label yet. Labels are AI-classified by Jev: advisory, not clinician-reviewed.

Papers over time

by publication year
469235 1990–942005–092025–26*

* 2025–26 is still in progress, so its count is incomplete.

Most-cited trials and reviews

by citations
  1. 1

    A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor.

    RCTSchuurman et al. · 2000 · 592 citations
  2. 2

    Deep brain stimulation for essential tremor: a systematic review.

    Systematic reviewFlora et al. · 2010 · 223 citations
  3. 3

    DBS of the PSA and the VIM in essential tremor: A randomized, double-blind, crossover trial.

    RCTBarbe et al. · 2018 · 117 citations
  4. 4

    PSA and VIM DBS efficiency in essential tremor depends on distance to the dentatorubrothalamic tract.

    RCTDembek et al. · 2020 · 60 citations · Open access
  5. 5

    Current clinical application of deep-brain stimulation for essential tremor.

    Systematic reviewChopra et al. · 2013 · 55 citations · Open access
  6. 6

    Randomized, Blinded Pilot Testing of Nonconventional Stimulation Patterns and Shapes in Parkinson's Disease and Essential Tremor: Evidence for Further Evaluating Narrow and Biphasic Pulses.

    RCTAkbar et al. · 2016 · 52 citations
  7. 7

    Less is more - Pulse width dependent therapeutic window in deep brain stimulation for essential tremor.

    RCTMoldovan et al. · 2018 · 35 citations
  8. 8

    Outcomes and Adverse Effects of Deep Brain Stimulation on the Ventral Intermediate Nucleus in Patients with Essential Tremor.

    Meta-analysisLu et al. · 2020 · 30 citations · Open access

Recent trials and reviews

last 3 years
  1. 1

    Tremor Associated With Klinefelter Syndrome: Report of a Case Treated by Deep Brain Stimulation and Systematic Review of the Literature.

    Systematic reviewDabboucy et al. · 2025 · 1 citations
  2. 2

    Comparative efficacy of PSA and VIM deep brain stimulation in essential tremor: a network and multilevel meta-analysis.

    Meta-analysisAghajanian et al. · 2025 · 0 citations
  3. 3

    Tremor in Spinocerebellar Ataxia: A Scoping Review.

    Systematic reviewMukherjee et al. · 2024 · 7 citations · Open access
  4. 4

    Deep brain stimulation with short versus conventional pulse width in Parkinson's disease and essential tremor: A systematic review and meta-analysis.

    Meta-analysisSmeets et al. · 2024 · 6 citations
  5. 5

    Cognitive outcomes in patients with essential tremor treated with deep brain stimulation: a systematic review.

    Systematic reviewAl Ali et al. · 2024 · 6 citations · Open access

Decision support only. This page summarises published literature; it is not medical advice or a recommendation for any patient. Study designs and topic labels are AI-classified by Jev: advisory, not clinician-reviewed. Abstracts are not reproduced here: follow the links to read each source. Data snapshot 2026-09-25.