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Evidence map · VNS · post-stroke arm rehabilitation

VNS for post-stroke arm rehabilitation: what the research shows

Paired vagus nerve stimulation for post-stroke arm rehabilitation. 322 papers from 1987 to 2026, including 23 meta-analyses, 12 systematic reviews and 43 randomised controlled trials. Each study below links to its source.

322Papers in the corpus
23Meta-analyses
43Randomised controlled trials
134Open-access papers

Study design

Jev labels
Meta-analysis23Systematic review12RCT43Non-randomised trial15Cohort4Cross-sectional1Case series2Case report13

40 papers have no confident study-design label yet. Labels are AI-classified by Jev: advisory, not clinician-reviewed.

Papers over time

by publication year
16080 1985–892005–092025–26*

* 2025–26 is still in progress, so its count is incomplete.

Most-cited trials and reviews

by citations
  1. 1

    Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial.

    RCTDawson et al. · 2021 · 361 citations
  2. 2

    Safety, Feasibility, and Efficacy of Vagus Nerve Stimulation Paired With Upper-Limb Rehabilitation After Ischemic Stroke.

    RCTDawson et al. · 2016 · 226 citations · Open access
  3. 3

    Vagus Nerve Stimulation Paired With Upper Limb Rehabilitation After Chronic Stroke.

    RCTKimberley et al. · 2018 · 143 citations
  4. 4

    Transcutaneous Vagus Nerve Stimulation Combined with Robotic Rehabilitation Improves Upper Limb Function after Stroke.

    RCTCapone et al. · 2017 · 108 citations · Open access
  5. 5

    Effect and Safety of Transcutaneous Auricular Vagus Nerve Stimulation on Recovery of Upper Limb Motor Function in Subacute Ischemic Stroke Patients: A Randomized Pilot Study.

    RCTWu et al. · 2020 · 75 citations · Open access
  6. 6

    Vagus nerve stimulation in ischemic stroke: old wine in a new bottle.

    Systematic reviewCai et al. · 2014 · 64 citations · Open access
  7. 7

    Efficacy and safety of transcutaneous auricular vagus nerve stimulation combined with conventional rehabilitation training in acute stroke patients: a randomized controlled trial conducted for 1 year involving 60 patients.

    RCTLi et al. · 2022 · 49 citations · Open access
  8. 8

    Transcutaneous Auricular Vagus Nerve Stimulation (tAVNS) Delivered During Upper Limb Interactive Robotic Training Demonstrates Novel Antagonist Control for Reaching Movements Following Stroke.

    RCTChang et al. · 2021 · 48 citations · Open access

Recent trials and reviews

last 3 years
  1. 1

    Closed-Loop Vagus Nerve Stimulation Delivered With a Miniaturized System Produces Lasting Recovery in Individuals With Chronic Stroke.

    RCTHays et al. · 2026 · 1 citations
  2. 2

    Vagus nerve stimulation to improve post-stroke motor function and activity.

    Meta-analysisEverard et al. · 2026 · 0 citations
  3. 3

    Transcutaneous Auricular Vagus nerve stimulation paired with exercise training for upper-limb motor function and activities of daily living after stroke: A systematic review and meta-analysis.

    Meta-analysisGao et al. · 2026 · 0 citations
  4. 4

    The Effect of Vagus Nerve Stimulation on the Rehabilitation of Stroke: A Systematic Review and Meta-analysis.

    Meta-analysisYu et al. · 2026 · 0 citations
  5. 5

    Exploring the Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation on Post-Stroke Oral Phase Dysphagia via Functional Near-Infrared Spectroscopy

    RCTDai et al. · 2026 · 0 citations

Decision support only. This page summarises published literature; it is not medical advice or a recommendation for any patient. Study designs and topic labels are AI-classified by Jev: advisory, not clinician-reviewed. Abstracts are not reproduced here: follow the links to read each source. Data snapshot 2026-09-25.