Evidence map · RNS · focal epilepsy
RNS for focal epilepsy: what the research shows
Responsive neurostimulation for focal epilepsy. 653 papers from 2004 to 2026, including 26 meta-analyses, 20 systematic reviews and 5 randomised controlled trials. Each study below links to its source.
653Papers in the corpus
26Meta-analyses
5Randomised controlled trials
207Open-access papers
Study design
Jev labels155 papers have no confident study-design label yet. Labels are AI-classified by Jev: advisory, not clinician-reviewed.
Papers over time
by publication year* 2025–26 is still in progress, so its count is incomplete.
Most-cited trials and reviews
by citations- 1
Responsive cortical stimulation for the treatment of medically intractable partial epilepsy.
- 2
Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: final results of the RNS System Pivotal trial.
- 3
Deep brain stimulation targets in epilepsy: Systematic review and meta-analysis of anterior and centromedian thalamic nuclei and hippocampus.
- 4
Neurostimulation for drug-resistant epilepsy: a systematic review of clinical evidence for efficacy, safety, contraindications and predictors for response.
- 5
Quality of life and mood in patients with medically intractable epilepsy treated with targeted responsive neurostimulation.
- 6
Neurostimulation in people with drug-resistant epilepsy: Systematic review and meta-analysis from the ILAE Surgical Therapies Commission.
- 7
A systematic review of deep brain stimulation for the treatment of drug-resistant epilepsy in childhood.
- 8
Neurostimulation in generalized epilepsy: A systematic review and meta-analysis.
Recent trials and reviews
last 3 years- 1
Epilepsy: Modern Treatment Approaches, Clinical Aspects, and Patent Status.
- 2
Comparative Efficacy of Interventions for Drug-Resistant Epilepsy: A Network Meta-analysis
- 3
Chronic Subthreshold Cortical Stimulation for Paracentral Epilepsy-A Systematic Review.
- 4
Comparative Efficacy of Neuromodulatory Strategies for Drug-Resistant Epilepsy: A Systematic Review and Meta-Analysis.
- 5
Responsive neurostimulation for patients with refractory mesial temporal lobe epilepsy: A systematic review and meta-analysis.
Decision support only. This page summarises published literature; it is not medical advice or a recommendation for any patient. Study designs and topic labels are AI-classified by Jev: advisory, not clinician-reviewed. Abstracts are not reproduced here: follow the links to read each source. Data snapshot 2026-09-25.