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Evidence map · BAT · heart failure

BAT for heart failure: what the research shows

Baroreflex activation therapy for heart failure. 163 papers from 1990 to 2026, including 8 meta-analyses, 3 systematic reviews and 7 randomised controlled trials. Each study below links to its source.

163Papers in the corpus
8Meta-analyses
7Randomised controlled trials
19Open-access papers

Study design

Jev labels
Meta-analysis8Systematic review3RCT7Non-randomised trial9Cohort4Cross-sectional1Case series4Case report9

40 papers have no confident study-design label yet. Labels are AI-classified by Jev: advisory, not clinician-reviewed.

Papers over time

by publication year
5226 1990–942005–092025–26*

* 2025–26 is still in progress, so its count is incomplete.

Most-cited trials and reviews

by citations
  1. 1

    Baroreflex Activation Therapy for the Treatment of Heart Failure With a Reduced Ejection Fraction.

    RCTAbraham et al. · 2015 · JACC. Heart failure · 277 citations
  2. 2

    Baroreflex Activation Therapy in Patients With Heart Failure With Reduced Ejection Fraction.

    RCTZile et al. · 2020 · Journal of the American College of Cardiology · 196 citations
  3. 3

    Baroreflex activation therapy for the treatment of heart failure with a reduced ejection fraction: safety and efficacy in patients with and without cardiac resynchronization therapy.

    RCTZile et al. · 2015 · European journal of heart failure · 97 citations
  4. 4

    Baroreflex activation therapy with the Barostim™ device in patients with heart failure with reduced ejection fraction: a patient level meta-analysis of randomized controlled trials.

    Meta-analysisCoats et al. · 2022 · European journal of heart failure · 43 citations · Open access
  5. 5

    Baroreflex activation therapy for the treatment of heart failure with reduced ejection fraction in patients with and without coronary artery disease.

    RCTHalbach et al. · 2018 · International journal of cardiology · 32 citations
  6. 6

    Surgical Experience and Long-term Results of Baroreflex Activation Therapy for Heart Failure With Reduced Ejection Fraction.

    RCTWeaver et al. · 2016 · Seminars in thoracic and cardiovascular surgery · 31 citations
  7. 7

    Baroreflex activation therapy in patients with heart failure and a reduced ejection fraction: Long-term outcomes.

    RCTZile et al. · 2024 · European journal of heart failure · 29 citations
  8. 8

    Updates on Baroreflex Activation Therapy and Vagus Nerve Stimulation for Treatment of Heart Failure With Reduced Ejection Fraction.

    Systematic reviewBabar et al. · 2022 · Cardiology research · 15 citations · Open access

Recent trials and reviews

last 3 years
  1. 1

    Network meta-analysis on efficacy of nerve stimulation or modulation in patients with heart failure.

    Meta-analysisTseng et al. · 2026 · Heart rhythm · 1 citations
  2. 2

    Phenotype characterization of heart failure with preserved ejection fraction in medical device and surgical trials.

    Systematic reviewAraz et al. · 2025 · ESC heart failure · 2 citations · Open access
  3. 3

    Baroreflex activation therapy in patients with heart failure and a reduced ejection fraction: Long-term outcomes.

    RCTZile et al. · 2024 · European journal of heart failure · 29 citations
  4. 4

    Non-pharmacologic autonomic neuromodulation for treatment of heart failure: A systematic review and meta-analysis of randomized controlled trials.

    Meta-analysisAhmed et al. · 2024 · Trends in cardiovascular medicine · 7 citations
  5. 5

    Baroreflex activation therapy for heart failure with reduced ejection fraction: A comprehensive systematic review and meta-analysis.

    Meta-analysisShi et al. · 2024 · Heliyon · 3 citations · Open access

Decision support only. This page summarises published literature; it is not medical advice or a recommendation for any patient. Study designs and topic labels are AI-classified by Jev: advisory, not clinician-reviewed. Abstracts are not reproduced here: follow the links to read each source. Data snapshot 2026-09-25.